The reactivity of the 2-deoxyribonolactone lesion in single-stranded DNA and its implication in reaction mechanisms of DNA damage and repair.

The formal C1'-oxidation product, 2-deoxyribonolactone, is formed as a result of DNA damage induced via a variety of agents, including gamma-radiolysis and the enediyne antitumor antibiotics. This alkaline labile lesion may also be an intermediate during DNA damage induced by copper-phenanthroline....

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Hwang, J T, Tallman, K A, Greenberg, M M
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 1999
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148643/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10481019/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.19.3805
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