A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1.

Eitemau Tebyg

• The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA binding by Pbx1.
  gan: Knoepfler, P S, et al.
  Cyhoeddwyd: (1995)
• Meis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1
  gan: Knoepfler, Paul S., et al.
  Cyhoeddwyd: (1997)
• Prep1 and Meis1 competition for Pbx1 binding regulates protein stability and tumorigenesis
  gan: Dardaei, Leila, et al.
  Cyhoeddwyd: (2014)
• Pbx-1 Hox heterodimers bind DNA on inseparable half-sites that permit intrinsic DNA binding specificity of the Hox partner at nucleotides 3' to a TAAT motif.
  gan: Knoepfler, P S, et al.
  Cyhoeddwyd: (1996)
• Purification and characterization of a DNA-binding recombinant PREP1:PBX1 complex.
  gan: Lisa Mathiasen, et al.
  Cyhoeddwyd: (2015-01-01)