A conserved motif N-terminal to the DNA-binding domains of myogenic bHLH transcription factors mediates cooperative DNA binding with pbx-Meis1/Prep1.

The t(1;19) chromosomal translocation of pediatric pre-B cell leukemia produces chimeric oncoprotein E2a-Pbx1, which contains the N-terminal transactivation domain of the basic helix-loop-helix (bHLH) transcription factor, E2a, joined to the majority of the homeodomain protein, Pbx1. There are three...

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Bibliographic Details
Main Authors: Knoepfler, P S, Bergstrom, D A, Uetsuki, T, Dac-Korytko, I, Sun, Y H, Wright, W E, Tapscott, S J, Kamps, M P
Format: Artigo
Language:Inglês
Published: 1999
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC148632/
https://ncbi.nlm.nih.gov/pubmed/10471746
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