Pbx-1 Hox heterodimers bind DNA on inseparable half-sites that permit intrinsic DNA binding specificity of the Hox partner at nucleotides 3' to a TAAT motif.

Ítems similars

• The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA binding by Pbx1.
  per: Knoepfler, P S, et al.
  Publicat: (1995)
• Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.
  per: Lu, Q, et al.
  Publicat: (1995)
• PBX and MEIS as Non-DNA-Binding Partners in Trimeric Complexes with HOX Proteins
  per: Shanmugam, Kandavel, et al.
  Publicat: (1999)
• Structural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complex.
  per: Lu, Q, et al.
  Publicat: (1996)
• Pbx raises the DNA binding specificity but not the selectivity of antennapedia Hox proteins.
  per: Neuteboom, S T, et al.
  Publicat: (1997)