Role of the locus and of the resistance gene on gene amplification frequency in methotrexate resistant Leishmania tarentolae.
The protozoan parasite Leishmania resists the antifolate methotrexate (MTX) by amplifying the R locus dihydrofolate reductase-thymidylate synthase ( dhfr-ts ) gene, the H locus ptr1 pterin reductase gene, and finally by mutation in a common folate/MTX transporter. Amplification of dhfr-ts has never...
Guardat en:
| Publicat a: | Nucleic Acids Res |
|---|---|
| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
1999
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148619/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10471733/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.18.3653 |
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