Role of the locus and of the resistance gene on gene amplification frequency in methotrexate resistant Leishmania tarentolae.

The protozoan parasite Leishmania resists the antifolate methotrexate (MTX) by amplifying the R locus dihydrofolate reductase-thymidylate synthase ( dhfr-ts ) gene, the H locus ptr1 pterin reductase gene, and finally by mutation in a common folate/MTX transporter. Amplification of dhfr-ts has never...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Kündig, C, Leblanc, E, Papadopoulou, B, Ouellette, M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 1999
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148619/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10471733/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.18.3653
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