Inhibition of luciferase expression by synthetic hammerhead ribozymes and their cellular uptake.

Two synthetic hammerhead ribozymes, one unmodified and the other with 2"-modifications and four phosphorothioate groups, targeting a single GUA site in the luciferase mRNA, were compared for their inhibition of gene expression in cell cultureand their cellular uptake was also analysed. A HeLa X1/5 c...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Bramlage, B, Alefelder, S, Marschall, P, Eckstein, F
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1999
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148543/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10454613/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.15.3159
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