Linkers designed to intercalate the double helix greatly facilitate DNA alkylation by triplex-forming oligonucleotides carrying a cyclopropapyrroloindole reactive moiety.

Triplex-forming oligonucleotides (TFOs) bind sequence-specifically in the major groove of double-stranded DNA. Cyclopropapyrroloindole (CPI), the electrophilic moiety that comprises the reactive subunit of the antibiotic CC-1065, gives hybridization-triggered alkylation at the N-3 position of adenin...

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Podrobná bibliografie
Vydáno v:	Nucleic Acids Res
Hlavní autoři:	Dempcy, R O, Kutyavin, I V, Mills, A G, Lukhtanov, E A, Meyer, R B
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Oxford University Press 1999
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC148509/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10390536/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/27.14.2931
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Linkers designed to intercalate the double helix greatly facilitate DNA alkylation by triplex-forming oligonucleotides carrying a cyclopropapyrroloindole reactive moiety.

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