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Chemical rescue, multiple ionizable groups, and general acid–base catalysis in the HDV genomic ribozyme
In the ribozyme from the hepatitis delta virus (HDV) genomic strand RNA, a cytosine side chain is proposed to facilitate proton transfer in the transition state of the reaction and, thus, act as a general acid–base catalyst. Mutation of this active-site cytosine (C75) reduced RNA cleavage rates by a...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Cold Spring Harbor Laboratory Press
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1484427/ https://ncbi.nlm.nih.gov/pubmed/16690998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.14106 |
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