Loading...
Chemical rescue, multiple ionizable groups, and general acid–base catalysis in the HDV genomic ribozyme
In the ribozyme from the hepatitis delta virus (HDV) genomic strand RNA, a cytosine side chain is proposed to facilitate proton transfer in the transition state of the reaction and, thus, act as a general acid–base catalyst. Mutation of this active-site cytosine (C75) reduced RNA cleavage rates by a...
Na minha lista:
| Main Authors: | , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2006
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1484427/ https://ncbi.nlm.nih.gov/pubmed/16690998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1261/rna.14106 |
| Tags: |
Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!
|