Flexibility in a Drug Transport Accessory Protein: Molecular Dynamics Simulations of MexA

Drug resistance in Gram-negative bacteria may be conferred via efflux through a tripartite complex of an inner membrane pump, an outer membrane pore, and a periplasmic adaptor protein. These are AcrB, TolC, and AcrA, respectively, in Escherichia coli. In Pseudomonas aerugonisa, their homologs are Me...

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Bibliographic Details
Main Authors: Vaccaro, Loredana, Koronakis, Vassilis, Sansom, Mark S. P.
Format: Artigo
Language:Inglês
Published: Biophysical Society 2006
Subjects:
Biophysical Theory and Modeling
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1483075/
https://ncbi.nlm.nih.gov/pubmed/16648168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.080010
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