Downregulation of uPA, uPAR and MMP-9 using small, interfering, hairpin RNA (siRNA) inhibits glioma cell invasion, angiogenesis and tumor growth

The diffuse, extensive infiltration of malignant gliomas into the surrounding normal brain is believed to rely on modification of the proteolysis of extracellular matrix components. Our previous results clearly demonstrate that uPA, uPAR and MMP-9 concentrations increase significantly during tumor p...

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Bibliographic Details
Main Authors: Gondi, Christopher S., Lakka, Sajani S., Dinh, Dzung H., Olivero, William C., Gujrati, Meena, Rao, Jasti S.
Format: Artigo
Language:Inglês
Published: 2004
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1483066/
https://ncbi.nlm.nih.gov/pubmed/16804563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/s1740925x04000237
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