Estrogens protect pancreatic β-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice

In diabetes, the death of insulin-producing β-cells by apoptosis leads to insulin deficiency. The lower prevalence of diabetes in females suggests that female sex steroids protect from β-cell injury. Consistent with this hypothesis, 17β-estradiol (estradiol) manifests antidiabetic actions in humans...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Le May, Cedric, Chu, Khoi, Hu, Min, Ortega, Christina S., Simpson, Evan R., Korach, Kenneth S., Tsai, Ming-Jer, Mauvais-Jarvis, Franck
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2006
Pynciau:
Biological Sciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482595/
https://ncbi.nlm.nih.gov/pubmed/16754860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602956103
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