Redox sensor CtBP mediates hypoxia-induced tumor cell migration

The rapid growth and poor vascularization of solid tumors expose cancer cells to hypoxia, which promotes the metastatic phenotype by reducing intercellular adhesion and increasing cell motility and invasiveness. In this study, we found that hypoxia increased free NADH levels in cancer cells, promoti...

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Bibliografiske detaljer
Main Authors: Zhang, Qinghong, Wang, Su-Yan, Nottke, Amanda C., Rocheleau, Jonathan V., Piston, David W., Goodman, Richard H.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482560/
https://ncbi.nlm.nih.gov/pubmed/16740659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603269103
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