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Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex

The Sir2 histone deacetylases are important for gene regulation, metabolism, and longevity. A unique feature of these enzymes is their utilization of NAD(+) as a cosubstrate, which has led to the suggestion that Sir2 activity reflects the cellular energy state. We show that SIRT1, a mammalian Sir2 h...

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Библиографические подробности
Главные авторы: Zhang, Qinghong, Wang, Su-Yan, Fleuriel, Capucine, Leprince, Dominique, Rocheleau, Jonathan V., Piston, David W., Goodman, Richard H.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2007
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783399/
https://ncbi.nlm.nih.gov/pubmed/17213307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610590104
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