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Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex

The Sir2 histone deacetylases are important for gene regulation, metabolism, and longevity. A unique feature of these enzymes is their utilization of NAD(+) as a cosubstrate, which has led to the suggestion that Sir2 activity reflects the cellular energy state. We show that SIRT1, a mammalian Sir2 h...

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Main Authors: Zhang, Qinghong, Wang, Su-Yan, Fleuriel, Capucine, Leprince, Dominique, Rocheleau, Jonathan V., Piston, David W., Goodman, Richard H.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1783399/
https://ncbi.nlm.nih.gov/pubmed/17213307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610590104
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