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Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex
The Sir2 histone deacetylases are important for gene regulation, metabolism, and longevity. A unique feature of these enzymes is their utilization of NAD(+) as a cosubstrate, which has led to the suggestion that Sir2 activity reflects the cellular energy state. We show that SIRT1, a mammalian Sir2 h...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2007
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1783399/ https://ncbi.nlm.nih.gov/pubmed/17213307 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610590104 |
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