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Histone modification-dependent and -independent pathways for recruitment of checkpoint protein Crb2 to double-strand breaks

Cellular responses to DNA damage involve the relocalization of checkpoint proteins to DNA double-strand breaks (DSBs). The fission yeast checkpoint mediator protein Crb2, a homolog of mammalian 53BP1, forms ionizing radiation-induced nuclear foci (IRIF). The IRIF formation by Crb2 requires histone H...

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Detalhes bibliográficos
Main Authors: Du, Li-Lin, Nakamura, Toru M., Russell, Paul
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482479/
https://ncbi.nlm.nih.gov/pubmed/16778077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1422606
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