Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome

Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder caused by mutations in the gene that encodes fibrillin-1. Selected manifestations of MFS reflect excessive signaling by the transforming growth factor–β (TGF-β) family of cytokines. We show that aortic aneurysm in...

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Bibliographic Details
Main Authors: Habashi, Jennifer P., Judge, Daniel P., Holm, Tammy M., Cohn, Ronald D., Loeys, Bart L., Cooper, Timothy K., Myers, Loretha, Klein, Erin C., Liu, Guosheng, Calvi, Carla, Podowski, Megan, Neptune, Enid R., Halushka, Marc K., Bedja, Djahida, Gabrielson, Kathleen, Rifkin, Daniel B., Carta, Luca, Ramirez, Francesco, Huso, David L., Dietz, Harry C.
Format: Artigo
Language:Inglês
Published: 2006
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482474/
https://ncbi.nlm.nih.gov/pubmed/16601194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1124287
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