Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome

Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder caused by mutations in the gene that encodes fibrillin-1. Selected manifestations of MFS reflect excessive signaling by the transforming growth factor–β (TGF-β) family of cytokines. We show that aortic aneurysm in...

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Detalhes bibliográficos
Main Authors: Habashi, Jennifer P., Judge, Daniel P., Holm, Tammy M., Cohn, Ronald D., Loeys, Bart L., Cooper, Timothy K., Myers, Loretha, Klein, Erin C., Liu, Guosheng, Calvi, Carla, Podowski, Megan, Neptune, Enid R., Halushka, Marc K., Bedja, Djahida, Gabrielson, Kathleen, Rifkin, Daniel B., Carta, Luca, Ramirez, Francesco, Huso, David L., Dietz, Harry C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482474/
https://ncbi.nlm.nih.gov/pubmed/16601194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1124287
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