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Structural basis of catalysis by monometalated methionine aminopeptidase

Methionine aminopeptidase (MetAP) removes the amino-terminal methionine residue from newly synthesized proteins, and it is a target for the development of antibacterial and anticancer agents. Available x-ray structures of MetAP, as well as other metalloaminopeptidases, show an active site containing...

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Sonraí Bibleagrafaíochta
Main Authors: Ye, Qi-Zhuang, Xie, Sheng-Xue, Ma, Ze-Qiang, Huang, Min, Hanzlik, Robert P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2006
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1480431/
https://ncbi.nlm.nih.gov/pubmed/16769889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0602433103
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