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Pitx2a Binds to Human Papillomavirus Type 18 E6 Protein and Inhibits E6-mediated P53 Degradation in HeLa Cells
Binding of high risk human papillomavirus (HPV) E6 protein to E6-associated protein (E6AP), a cellular ubiquitin-protein ligase, enables E6AP to ubiquitinate p53, leading to p53 degradation in cervical cancer cells such as HeLa cells. Here we report that Pitx2a, a bicoid-type homeodomain transcripti...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1479768/ https://ncbi.nlm.nih.gov/pubmed/16129685 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M502974200 |
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