TYK2 activity promotes ligand-induced IFNAR1 proteolysis

The type I IFNR (interferon receptor) is a heterodimer composed of two transmembrane chains, IFNAR1 (interferon-α receptor 1 subunit) and IFNAR2, which are associated with the tyrosine kinases Tyk2 and Jak1 (Janus kinase 1) respectively. Ligand-induced down-regulation of the type I IFNR is a major m...

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Autores principales: Marijanovic, Zrinka, Ragimbeau, Josiane, Kumar, K. G. Suresh, Fuchs, Serge Y., Pellegrini, Sandra
Formato: Artigo
Lenguaje:Inglês
Publicado: Portland Press Ltd. 2006
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479745/
https://ncbi.nlm.nih.gov/pubmed/16551269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20060272
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