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A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation

Some genes on the inactive X chromosome escape silencing. One possible escape mechanism is that heterochromatization during X inactivation can be blocked by boundary elements. DNA insulators are candidates for blocking because they shield genes from influences of their chromosomal environment. To te...

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Bibliografiske detaljer
Main Authors: Ciavatta, Dominic, Kalantry, Sundeep, Magnuson, Terry, Smithies, Oliver
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2006
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479543/
https://ncbi.nlm.nih.gov/pubmed/16777957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0603754103
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