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The Polycomb Group Protein EED Is Dispensable for the Initiation of Random X-Chromosome Inactivation

The Polycomb group (PcG) proteins are thought to silence gene expression by modifying chromatin. The Polycomb repressive complex 2 (PRC2) plays an essential role in mammalian X-chromosome inactivation (XCI), a model system to investigate heritable gene silencing. In the mouse, two different forms of...

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Bibliographic Details
Main Authors: Kalantry, Sundeep, Magnuson, Terry
Format: Artigo
Language:Inglês
Published: Public Library of Science 2006
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1456320/
https://ncbi.nlm.nih.gov/pubmed/16680199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.0020066
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