Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator

BACKGROUND: Urokinase-type plasminogen activator (uPA) plays a major role in extracellular proteolytic events associated with tumor cell growth, migration and angiogenesis. Consequently, uPA is an attractive target for the development of small molecule active site inhibitors. Most of the recent drug...

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Главные авторы: Heynekamp, Justin J, Hunsaker, Lucy A, Vander Jagt, Thomas A, Deck, Lorraine M, Vander Jagt, David L
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2006
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479381/
https://ncbi.nlm.nih.gov/pubmed/16466576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6769-6-1
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