Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator

BACKGROUND: Urokinase-type plasminogen activator (uPA) plays a major role in extracellular proteolytic events associated with tumor cell growth, migration and angiogenesis. Consequently, uPA is an attractive target for the development of small molecule active site inhibitors. Most of the recent drug...

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Autors principals: Heynekamp, Justin J, Hunsaker, Lucy A, Vander Jagt, Thomas A, Deck, Lorraine M, Vander Jagt, David L
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2006
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479381/
https://ncbi.nlm.nih.gov/pubmed/16466576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6769-6-1
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