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4'-Acylated thymidine 5'-triphosphates: a tool to increase selectivity towards HIV-1 reverse transcriptase.

4'-Acylated thymidines represent a new class of DNA chain terminators, since they have been shown to act as post-incorporation chain-terminating nucleotides despite the presence of a free 3'-hydroxyl group. Here, we describe the action of the 4'-acetyl- (MeTTP) and 4'-propanoylthymidine 5'-triphosph...

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Udgivet i:Nucleic Acids Res
Principais autores: Marx, A, Amacker, M, Stucki, M, Hübscher, U, Bickle, T A, Giese, B
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1998
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147810/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9705520/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.17.4063
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