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Conferring RNA polymerase Activity to a DNA polymerase: A single residue in reverse transcriptase controls substrate selection

The traditional classification of nucleic acid polymerases as either DNA or RNA polymerases is based, in large part, on their fundamental preference for the incorporation of either deoxyribonucleotides or ribonucleotides during chain elongation. The refined structure determination of Moloney murine...

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Main Authors: Gao, Guangxia, Orlova, Marianna, Georgiadis, Millie M., Hendrickson, Wayne A., Goff, Stephen P.
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences of the USA 1997
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC19524/
https://ncbi.nlm.nih.gov/pubmed/9012795
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