Lung adenocarcinomas induced in mice by mutant EGF receptors foundin human lung cancers respondto a tyrosine kinase inhibitor orto down-regulation of the receptors

Somatic mutations in exons encoding the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) gene are found in human lung adenocarcinomas and are associated with sensitivity to the tyrosine kinase inhibitors gefitinib and erlotinib. Nearly 90% of the EGFR mutations are either short,...

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Bibliographic Details
Main Authors:	Politi, Katerina, Zakowski, Maureen F., Fan, Pang-Dian, Schonfeld, Emily A., Pao, William, Varmus, Harold E.
Format:	Artigo
Language:	Inglês
Published:	Cold Spring Harbor Laboratory Press 2006
Subjects:	Research Paper
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC1475762/ https://ncbi.nlm.nih.gov/pubmed/16705038 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1417406
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Lung adenocarcinomas induced in mice by mutant EGF receptors foundin human lung cancers respondto a tyrosine kinase inhibitor orto down-regulation of the receptors

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