Mismatched nucleotides may facilitate expansion of trinucleotide repeats in genetic diseases.
We have studied the contribution of mismatch sequences to the trinucleotide repeat expansion that causes hereditary diseases. Using an oligonucleotide duplex, (CAG)5/(CTG)5, as a template-primer, DNA synthesis was carried out using either Escherichia coli DNA polymerase I (Klenow fragment) or human...
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| Publicado no: | Nucleic Acids Res |
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| Principais autores: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
1998
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147492/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9518492/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.8.1980 |
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