Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity

Resistance to chemotherapy presents a serious challenge in the successful treatment of various cancers and is mainly responsible for mortality associated with disseminated cancers. Here we show that expression of HtrA1, which is frequently downregulated in ovarian cancer, influences tumor response t...

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Bibliographic Details
Main Authors: Chien, Jeremy, Aletti, Giovanni, Baldi, Alfonso, Catalano, Vincenzo, Muretto, Pietro, Keeney, Gary L., Kalli, Kimberly R., Staub, Julie, Ehrmann, Michael, Cliby, William A., Lee, Yean Kit, Bible, Keith C., Hartmann, Lynn C., Kaufmann, Scott H., Shridhar, Viji
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2006
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1474818/
https://ncbi.nlm.nih.gov/pubmed/16767218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI27698
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