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Triplex targeting of a native gene in permeabilized intact cells: covalent modification of the gene for the chemokine receptor CCR5.

A 12 nucleotide oligodeoxyribopurine tract in the gene for the chemokine receptor CCR5 has been targeted and covalently modified in intact cells by a 12mer triplex forming oligonucleotide (TFO) bearing a reactive group. A nitrogen mustard placed on the 5'-end of the purine motif TFO modified a guani...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Belousov, E S, Afonina, I A, Kutyavin, I V, Gall, A A, Reed, M W, Gamper, H B, Wydro, R M, Meyer, R B
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 1998
Schlagworte:
Research Article
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147384/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9469844/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.5.1324
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