Triplex targeting of a native gene in permeabilized intact cells: covalent modification of the gene for the chemokine receptor CCR5.

A 12 nucleotide oligodeoxyribopurine tract in the gene for the chemokine receptor CCR5 has been targeted and covalently modified in intact cells by a 12mer triplex forming oligonucleotide (TFO) bearing a reactive group. A nitrogen mustard placed on the 5'-end of the purine motif TFO modified a...

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Detalhes bibliográficos
Main Authors: Belousov, E S, Afonina, I A, Kutyavin, I V, Gall, A A, Reed, M W, Gamper, H B, Wydro, R M, Meyer, R B
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC147384/
https://ncbi.nlm.nih.gov/pubmed/9469844
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