Efficient activation of nucleoside phosphoramidites with 4,5-dicyanoimidazole during oligonucleotide synthesis.

A new activator for the coupling of phosphoramidites to the 5'-hydroxyl group during oligonucleotide synthesis is introduced. The observed time to complete coupling is twice as fast with 4, 5-dicyanoimidazole (DCI) as the activator, compared with 1 H -tetrazole. The effectiveness of DCI is thou...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Vargeese, C, Carter, J, Yegge, J, Krivjansky, S, Settle, A, Kropp, E, Peterson, K, Pieken, W
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 1998
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC147346/
https://ncbi.nlm.nih.gov/pubmed/9461466
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