Efficient activation of nucleoside phosphoramidites with 4,5-dicyanoimidazole during oligonucleotide synthesis.

A new activator for the coupling of phosphoramidites to the 5'-hydroxyl group during oligonucleotide synthesis is introduced. The observed time to complete coupling is twice as fast with 4, 5-dicyanoimidazole (DCI) as the activator, compared with 1 H -tetrazole. The effectiveness of DCI is thought t...

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Bibliografiske detaljer

Udgivet i:	Nucleic Acids Res
Principais autores:	Vargeese, C, Carter, J, Yegge, J, Krivjansky, S, Settle, A, Kropp, E, Peterson, K, Pieken, W
Format:	Artigo
Sprog:	Inglês
Udgivet:	Oxford University Press 1998
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147346/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9461466/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/26.4.1046
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