Efficient activation of nucleoside phosphoramidites with 4,5-dicyanoimidazole during oligonucleotide synthesis.

A new activator for the coupling of phosphoramidites to the 5'-hydroxyl group during oligonucleotide synthesis is introduced. The observed time to complete coupling is twice as fast with 4, 5-dicyanoimidazole (DCI) as the activator, compared with 1 H -tetrazole. The effectiveness of DCI is thou...

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Bibliographic Details
Main Authors: Vargeese, C, Carter, J, Yegge, J, Krivjansky, S, Settle, A, Kropp, E, Peterson, K, Pieken, W
Format: Artigo
Language:Inglês
Published: 1998
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC147346/
https://ncbi.nlm.nih.gov/pubmed/9461466
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