THE STRUCTURE OF LEISHMANIA MEXICANA ICP PROVIDES EVIDENCE FOR CONVERGENT EVOLUTION OF CYSTEINE PEPTIDASE INHIBITORS

Clan CA, family C1 cysteine peptidases (CPs) are important virulence factors and drug targets in parasites that cause neglected diseases. Natural CP inhibitors of the I42 family, known as ICP, occur in some protozoa and bacterial pathogens, but are absent from metazoa. They are active against both p...

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Main Authors: Smith, Brian O., Picken, Nichola C., Westrop, Gareth D., Bromek, Krystyna, Mottram, Jeremy C., Coombs, Graham H.
Format: Artigo
Jezik:Inglês
Izdano: 2005
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1473161/
https://ncbi.nlm.nih.gov/pubmed/16407198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M510868200
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