Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

Multiple nonnucleoside inhibitor binding sites have been identified within the hepatitis C virus (HCV) polymerase, including in the palm and thumb domains. After a single treatment with a thumb site inhibitor (thiophene-2-carboxylic acid NNI-1), resistant HCV replicon variants emerged that contained...

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Autori principali: Le Pogam, Sophie, Kang, Hyunsoon, Harris, Seth F., Leveque, Vincent, Giannetti, Anthony M., Ali, Samir, Jiang, Wen-Rong, Rajyaguru, Sonal, Tavares, Gisele, Oshiro, Connie, Hendricks, Than, Klumpp, Klaus, Symons, Julian, Browner, Michelle F., Cammack, Nick, Nájera, Isabel
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2006
Soggetti:
Vaccines and Antiviral Agents
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472602/
https://ncbi.nlm.nih.gov/pubmed/16731953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02628-05
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