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Low-frequency normal modes that describe allosteric transitions in biological nanomachines are robust to sequence variations

By representing the high-resolution crystal structures of a number of enzymes using the elastic network model, it has been shown that only a few low-frequency normal modes are needed to describe the large-scale domain movements that are triggered by ligand binding. Here we explore a link between the...

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Bibliografski detalji
Glavni autori: Zheng, Wenjun, Brooks, Bernard R., Thirumalai, D.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2006
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472502/
https://ncbi.nlm.nih.gov/pubmed/16682636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0510426103
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