SOX2 is a dose-dependent regulator of retinal neural progenitor competence

Approximately 10% of humans with anophthalmia (absent eye) or severe microphthalmia (small eye) show haploid insufficiency due to mutations in SOX2, a SOXB1-HMG box transcription factor. However, at present, the molecular or cellular mechanisms responsible for these conditions are poorly understood....

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Autors principals: Taranova, Olena V., Magness, Scott T., Fagan, B. Matthew, Wu, Yongqin, Surzenko, Natalie, Hutton, Scott R., Pevny, Larysa H.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2006
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472477/
https://ncbi.nlm.nih.gov/pubmed/16651659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1407906
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