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SOX2 is a dose-dependent regulator of retinal neural progenitor competence
Approximately 10% of humans with anophthalmia (absent eye) or severe microphthalmia (small eye) show haploid insufficiency due to mutations in SOX2, a SOXB1-HMG box transcription factor. However, at present, the molecular or cellular mechanisms responsible for these conditions are poorly understood....
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Cold Spring Harbor Laboratory Press
2006
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1472477/ https://ncbi.nlm.nih.gov/pubmed/16651659 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1407906 |
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