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Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6

In humans, haploinsufficiency of either SOX2 or PAX6 is associated with microphthalmia, anophthalmia or aniridia. In this study, through the genetic spatiotemporal specific ablation of SOX2 on both wild-type and Pax6-haploinsufficent backgrounds in the mouse, we have uncovered a transcriptionally di...

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Détails bibliographiques
Auteurs principaux: Matsushima, Danielle, Heavner, Whitney, Pevny, Larysa H.
Format: Artigo
Langue:Inglês
Publié: Company of Biologists 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014633/
https://ncbi.nlm.nih.gov/pubmed/21205789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.055178
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