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Combinatorial regulation of optic cup progenitor cell fate by SOX2 and PAX6

In humans, haploinsufficiency of either SOX2 or PAX6 is associated with microphthalmia, anophthalmia or aniridia. In this study, through the genetic spatiotemporal specific ablation of SOX2 on both wild-type and Pax6-haploinsufficent backgrounds in the mouse, we have uncovered a transcriptionally di...

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Hlavní autoři: Matsushima, Danielle, Heavner, Whitney, Pevny, Larysa H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Company of Biologists 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3014633/
https://ncbi.nlm.nih.gov/pubmed/21205789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.055178
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