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Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription
We investigated the role of SIRT7, one of the seven members of the mammalian sirtuin family. We show that SIRT7 is a widely expressed nucleolar protein that is associated with active rRNA genes (rDNA), where it interacts with RNA polymerase I (Pol I) as well as with histones. Overexpression of SIRT7...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2006
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1472467/ https://ncbi.nlm.nih.gov/pubmed/16618798 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.1399706 |
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