Defective regulatory and effector T cell functions in patients with FOXP3 mutations

The autoimmune disease immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) is caused by mutations in the forkhead box protein P3 (FOXP3) gene. In the mouse model of FOXP3 deficiency, the lack of CD4(+)CD25(+) Tregs is responsible for lethal autoimmunity, indicating that FOXP3 is r...

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Main Authors: Bacchetta, Rosa, Passerini, Laura, Gambineri, Eleonora, Dai, Minyue, Allan, Sarah E., Perroni, Lucia, Dagna-Bricarelli, Franca, Sartirana, Claudia, Matthes-Martin, Susanne, Lawitschka, Anita, Azzari, Chiara, Ziegler, Steven F., Levings, Megan K., Roncarolo, Maria Grazia
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2006
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472239/
https://ncbi.nlm.nih.gov/pubmed/16741580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25112
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