Functional type 1 regulatory T cells develop regardless of FOXP3 mutations in patients with IPEX syndrome

Mutations of forkhead box p3 (FOXP3), the master gene for naturally occurring regulatory T cells (nTregs), are responsible for the impaired function of nTregs, resulting in an autoimmune disease known as the immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. The relevan...

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Autori principali: Passerini, Laura, Di Nunzio, Sara, Gregori, Silvia, Gambineri, Eleonora, Cecconi, Massimiliano, Seidel, Markus G, Cazzola, Giantonio, Perroni, Lucia, Tommasini, Alberto, Vignola, Silvia, Guidi, Luisa, Roncarolo, Maria G, Bacchetta, Rosa
Natura: Artigo
Lingua:Inglês
Pubblicazione: WILEY-VCH Verlag 2011
Soggetti:
Clinical Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3107421/
https://ncbi.nlm.nih.gov/pubmed/21400500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201040909
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