Pharmacodynamics of Levofloxacin against Pseudomonas aeruginosa with Reduced Susceptibility Due to Different Efflux Pumps: Do Elevated MICs Always Predict Reduced In Vivo Efficacy?

The Pseudomonas aeruginosa efflux pumps MexAB-OprM, MexCD-OprJ, and MexEF-OprN play an important role in susceptibility to fluoroquinolones in vitro. To determine if levofloxacin MICs arising from different levels of expression of efflux pumps result in a proportional reduction in the response to le...

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Detalhes bibliográficos
Main Authors: Griffith, David C., Corcoran, Erik, Lofland, Denene, Lee, Angela, Cho, Deidre, Lomovskaya, Olga, Dudley, Michael N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472187/
https://ncbi.nlm.nih.gov/pubmed/16641428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.50.5.1628-1632.2006
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