Use of an Efflux Pump Inhibitor To Determine the Prevalence of Efflux Pump-Mediated Fluoroquinolone Resistance and Multidrug Resistance in Pseudomonas aeruginosa

Fluoroquinolone-resistance in Pseudomonas aeruginosa may be due to efflux pump overexpression (EPO) and/or target mutations. EPO can result in multidrug resistance (MDR) due to broad substrate specificity of the pumps. MC-04,124, an efflux pump inhibitor (EPI) shown to significantly potentiate activ...

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Autores principales: Kriengkauykiat, Jane, Porter, Edith, Lomovskaya, Olga, Wong-Beringer, Annie
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
Materias:
Mechanisms of Resistance
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC547318/
https://ncbi.nlm.nih.gov/pubmed/15673734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.2.565-570.2005
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