The K65R Mutation in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Exhibits Bidirectional Phenotypic Antagonism with Thymidine Analog Mutations

The K65R mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) is selected in vitro by many d-nucleoside analog RT inhibitors (NRTI) but has been rarely detected in treated patients. In recent clinical trials, the K65R mutation has emerged frequently in patients experien...

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Bibliographic Details
Main Authors: Parikh, Urvi M., Bacheler, Lee, Koontz, Dianna, Mellors, John W.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2006
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472090/
https://ncbi.nlm.nih.gov/pubmed/16641288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.10.4971-4977.2006
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