Mice Develop Effective but Delayed Protective Immune Responses When Immunized as Neonates either Intranasally with Nonliving VP6/LT(R192G) or Orally with Live Rhesus Rotavirus Vaccine Candidates

Rotavirus vaccines are delivered early in life, when the immune system is immature. To determine the effects of immaturity on responses to candidate vaccines, neonatal (7 days old) and adult mice were immunized with single doses of either Escherichia coli-expressed rotavirus VP6 protein and the adju...

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Detalhes bibliográficos
Main Authors: VanCott, John L., Prada, Anne E., McNeal, Monica M., Stone, Susan C., Basu, Mitali, Huffer, Bert, Smiley, Kristi L., Shao, Mingyuan, Bean, Judy A., Clements, John D., Choi, Anthony H.-C., Ward, Richard L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472046/
https://ncbi.nlm.nih.gov/pubmed/16641286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.80.10.4949-4961.2006
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