CD4 T Cells Are the Only Lymphocytes Needed To Protect Mice against Rotavirus Shedding after Intranasal Immunization with a Chimeric VP6 Protein and the Adjuvant LT(R192G)

Intranasal immunization of mice with a chimeric VP6 protein and the mucosal adjuvant Escherichia coli heat labile toxin LT(R192G) induces nearly complete protection against murine rotavirus (strain EDIM [epizootic diarrhea of infant mice virus]) shedding for at least 1 year. The aim of this study wa...

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Detalhes bibliográficos
Main Authors: McNeal, Monica M., VanCott, John L., Choi, Anthony H. C., Basu, Matili, Flint, Jason A., Stone, Susan C., Clements, John D., Ward, Richard L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC136815/
https://ncbi.nlm.nih.gov/pubmed/11752147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.2.560-568.2002
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