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Kinetics of Insulin Aggregation: Disentanglement of Amyloid Fibrillation from Large-Size Cluster Formation

Kinetics of human insulin aggregation has been studied at pH 1.6 and 60°C, when amyloid fibrils are formed. We developed a novel approach based on the analysis of scattered light intensity distribution, which allows distinguishing between small and large size aggregates. By this method, we observed...

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Detalhes bibliográficos
Main Authors: Manno, Mauro, Craparo, Emanuela Fabiola, Martorana, Vincenzo, Bulone, Donatella, San Biagio, Pier Luigi
Formato: Artigo
Idioma:Inglês
Publicado em: Biophysical Society 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1471846/
https://ncbi.nlm.nih.gov/pubmed/16581839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.105.077636
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