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Higher fidelity of RNA-dependent DNA mispair extension by M184V drug-resistant than wild-type reverse transcriptase of human immunodeficiency virus type 1.

Reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) has low fidelity compared with RTs of other retroviruses and cellular DNA polymerases. We and others have previously found that the fidelity of DNA-dependent DNA polymerization (DDDP) of M184V-mutated HIV-1 RT is significantly...

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Udgivet i:Nucleic Acids Res
Principais autores: Hsu, M, Inouye, P, Rezende, L, Richard, N, Li, Z, Prasad, V R, Wainberg, M A
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1997
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC147088/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9358162/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/25.22.4532
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